Imaging Reveals Pathways Behind Depression (IMAGE)

Radiological Society of North America

Imaging Reveals Pathways Behind Depression

Caption

Overview of the computational modeling study. MRI is performed to obtain functional MRI (fMRI) and diffusion MRI (dMRI) data of the patient. Functional connectivity (FC) and structural connectivity (SC) are computed based on fMRI blood-oxygen-level-dependent (BOLD) signals and dfMRI tractography. The SC and FC information is used as input to the computational model which generates simulated neural activity and corresponding simulated BOLD signals, together with estimates of the intra-regional and inter-regional connectivity parameters. Predictions about the pathophysiological mechanisms of major depressive disorder (MDD) can then be made by comparing the connectivity parameter estimates of normal control (NC) patients with individuals with MDD.

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