Summary of this Study (IMAGE)

University of Tokyo

Summary of this Study

Caption

Progranulin derived from Purkinje cells (PCs) counteracts synapse elimination and reinforces the strongest (winner) climbing fiber (CF). Progranulin acts on developing CF synapses from Postnatal day 11 to 16 independently of Semaphorin3A, another retrograde signaling molecule that counteracts CF synapse elimination. Progranulin derived from PCs acts retrogradely onto its putative receptor Sort1 on CFs. Loser CFs are maintained by progranulin-Sort1 signal and Semaphorin3A-PlexinA4 signal, but they are eventually pruned by "elimination signals" such as Semaphorin7A and brain-derived neurotrophic factor (BDNF).

Credit

2018 Masanobu Kano.

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