Control of the Unfolded Protein Response in Health and Disease (IMAGE)

SLAS (Society for Laboratory Automation and Screening)

Control of the Unfolded Protein Response in Health and Disease

Caption

The three endoplasmic reticulum (ER) stress sensors (PERK [red], IRE1 [blue], ATF6 [green]) initially activate signaling events that increase protein-folding capacity and reduce protein load on the ER. These transcriptional and translational outputs tend to reestablish protein-folding homeostasis in the ER and promote cell survival.

Credit

Eric Chevet et al.

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