Graphical Abstract (IMAGE) AlphaMed Press Caption A bioengineered scaffold containing hypoxia-preconditioned, allogeneic human MSCs combined with a beta-adrenergic antagonist, timolol, to treat diabetic wounds in mice. The optimized treatment improved re-epithelialization by 65.6% with the beneficial effects of decreasing inflammation and promoting angiogenesis. This study provides preclinical evidence supporting the translation of this MSC-based treatment as a therapy for patients with chronic wounds. Credit AlphaMed Press Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.