Slipping Antibodies Into The Alzheimer's Brain (4 of 5) (VIDEO)

American Association for the Advancement of Science (AAAS)

Caption

Anti-TfR/BACE1 – red is the neurons in the brain and green is the antibody stain showing that the engineered antibody can get into the brain and bind to neurons. This video relates to a paper that appeared in the May 25, 2011, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. Y.J. Yu of Genentech Inc. in South San Francisco, Calif., and colleagues, was titled, “Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target.”

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Video © 2011 Genentech, Inc.

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