Visualization of Amylin Protofilaments (IMAGE)

University of Leeds

Visualization of Amylin Protofilaments

Caption

The image shows the structure of the amyloid fibrils in the wild-type amylin and also in the S20G variant. On the left of the image, fibrils from wild-type amylin are made up from layers containing two molecules that are stacked side by side. In the S20G variant, there is a third molecule per layer. This structural arrangement could lead to a greater propensity for aggregation.

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Please credit: University of Leeds

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