Identification of Human Common Monocyte Progenitor (cMoP) (IMAGE)

Tokyo Medical and Dental University

Identification of Human Common Monocyte Progenitor (cMoP)

Caption

Monocytes arise from hematopoietic stem cells (HSCs) via sequential intermediate progenitors in the bone marrow (BM), and inflammation can prompt tissue-infiltrating inflammatory monocytes to differentiate into macrophages and monocyte-derived dendritic cells (DCs), which are associated with inflammatory diseases. A common monocyte progenitor (cMoP) that is restricted to the monocyte lineage has been identified in mice but not in humans.

Credit

Department of Biodefense Research, Medical Research Institute,TMDU

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