Mechanisms that Maintain the Separation of Blood Vessels and Lymph Vessels (IMAGE)

Kumamoto University

Mechanisms that Maintain the Separation of Blood Vessels and Lymph Vessels

Caption

Normally, FLCN keeps the transcription factor TFE3 in the cytoplasm and suppresses the expression of Prox1 in veins. When FLCN is deleted, TFE3 migrates into the nucleus and Prox1 is expressed resulting in the appearance of venous endothelial cells that resemble lymphatic vessels. In other words, FLCN acts as a gatekeeper that regulates the plasticity of blood and lymphatic vessels, maintaining the separation between them.

Credit

Associate Professor Masaya Baba

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<p>Adapted from Fig. 7(o) of <a href="https://www.nature.com/articles/s41467-020-20156-6">Tai-Nagara, I. et.al., Nature Communications 2020</a>. These images have been modified for use in this press release. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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