Signs of MDS (IMAGE) Cincinnati Children's Hospital Medical Center Caption This microscopic image of myeloid cells taken from a genetic mouse model shows signs of the blood disease MDS (myelodysplastic syndromes), which can lead to leukemia. Instead of the normal appearance of myeloid blood cells--a smooth, round, donut-shape with a single nucleus--cells with MDS are underdeveloped, have multiple nuclei or are hyper-segmented. Researchers report in the journal Cancer Discovery identifying a gene called HIF1A that drives molecular processes leading to the diverse types of MDS disorders that affect people, opening the future possibility of developing new therapeutics for MDS. Credit Cincinnati Children's Usage Restrictions Please credit Cincinnati Children's License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.