Brain Stimulation (IMAGE) University of Iowa Health Care Caption The image illustrates changes in prefrontal brain activity when the subthalamic nucleus (STN) is stimulated at: high frequencies (right head), not stimulated at all (left head), or stimulated at 4 Hz (middle head). Stimulating the STN at 4 Hz produces a significant increase in frontal activity (also at 4 Hz), which correlates with improved patient performance on a simple cognitive task that is usually disrupted by Parkinson's disease (PD). The findings by neuroscientists at the University of Iowa and published Nov. 28 in the journal Brain, suggest that low frequency stimulation of the STN may provide an approach for treating cognitive symptoms of PD, and possibly other cognitive diseases. Credit Narayanan Lab, University of Iowa Usage Restrictions May be used with permission for educational or informational purposes only. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.