Rev-erb-alpha Double Duty (IMAGE) University of Pennsylvania School of Medicine Caption Model depicting distinct mechanisms of Rev-erb-alpha regulating clock and metabolic genes in the liver. Grey refers to other transcription factors that may be involved in tethering Rev-erb-alpha. Credit Mitchell Lazar, M.D., Ph.D., Perelman School of Medicine, University of Pennsylvania; Science Express Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.