Sweet control of longevity factor: Yin-Yan effect (IMAGE)

Tata Institute of Fundamental Research

Sweet control of longevity factor: Yin-Yan effect

Caption

During starvation, the longevity factor SIRT1 regulates glucose production and fat breakdown in the liver to provide energy to the body. Upon feeding, glucose dependent modification of SIRT1 (glycosylation), allows the liver to transit to a fed state, where it efficiently assimilates nutrients from the food to build cellular reserves of fat and glycogen. Whereas excessive glucose dependent glycosylation of SIRT1 in the liver results in obesity and aging, inability to undergo glycosylation also causes failure to respond to nutrient cues, insulin resistance and hyper-inflammation. Thus, our study shows that both de/-modification of SIRT1 is essential for metabolic flexibility of the liver and has immense therapeutic potential.

Credit

Babukrishna Maniyadath, Tandrika Chattopadhyay and Ullas Kolthur

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