Genetically Modified Granular Cells (IMAGE) Heidelberg University Hospital Caption These are genetically modified granular cells of the olfactory bulb in a mouse. The nuclei of the granular cells have been marked red by immunohistochemical staining. Cells that express an additional protein through viral gene transfer are green or yellow (see arrows). The virally expressed cre recombinase can modify the genetic material highly specifically in genetically modified mice. In the case presented, a certain glutamate receptor was removed from a large portion of the granular cells in this way, which resulted in the increased inhibition of the output cells of the olfactory bulb, leading to accelerated discrimination of odors. Credit Source: Institute of Anatomy and Cell Biology, Heidelberg University Hospital. Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.