Tumor Microenvironment of Metastasis (IMAGE)

Albert Einstein College of Medicine

Tumor Microenvironment of Metastasis

Caption

Metastasis requires the presence of three cells in the same microanatomic site: a tumor cell that produces the protein MENA; a macrophage (cells that guide tumor cells to blood vessels); and a blood-vessel endothelial cell. The presence of three such cells in contact with each other is called a tumor microenvironment of metastasis, or TMEM, which is depicted within the rectangle in this illustration.

Credit

Courtesy Clinical Cancer Research

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