JNCL on the Protein Level (IMAGE)
Caption
With the help of MELC microscopy, it is possible to visualize the location of large number of different proteins in the same cells by sequential staining. Compared to the healthy cells of the wild type (left), the cells of mice suffering from JNCL (right) are smaller, and the distribution of the proteins seems "disordered." Some structures are lost, others seem pathologically bloated, as can be seen in the structures colored in green. While the cells of the wild type exhibit a regular staining, large round accumulations are present in mutants.
Credit
Anton Petcherski, Goethe-University.
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