Two for the Price of One: Mechanistic Insights Lead to Drug Repositioning (IMAGE)

University of Tsukuba

Two for the Price of One: Mechanistic Insights Lead to Drug Repositioning

Caption

Molecular mechanism at a glance. SFN binds with SKP1 to sequester it in cytoplasm,resulting in the obstruction of SCFFBW7 598 complex formation. Oncoproteins including cyclin E1 and 599 c-Jun subsequently evade from ubiquitination and proteasomal degradation and are stabilized due to 600 lack of their specific E3 ubiquitin ligase.

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University of Tsukuba

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