POT1 Gene (IMAGE)

Centro Nacional de Investigaciones Oncológicas (CNIO)

POT1 Gene

Caption

The replacement of the amino acid arginine by a cysteine at position 117 in POT1p.R117C produces conformational changes in the protein that are incompatible with an efficient connection to the telomere, inducing an aberrant telomere elongation and fragile telomeres in the mutated cells.

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CNIO

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