How Obesity Worsens Blood Vessel Disease in Patients (1 of 1) (IMAGE)

American Association for the Advancement of Science (AAAS)

How Obesity Worsens Blood Vessel Disease in Patients (1 of 1)

Caption

Obesity results in increased production of Wnt5a from perivascular adipose tissue (PVAT) and visceral adipose tissue (such thoracic adipose tissue, ThAT) resulting in increased bioavailability of Wnt5a relative to its inhibitor Sfrp5. This could be a novel target against obesity-associated cardiac events such as heart attacks. This material relates to a paper that appeared in the Sept. 18, 2019, issue of Science Translational Medicine, published by AAAS. The paper, by I. Akoumianakis at University of Oxford in Oxford, UK; and colleagues was titled, "Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases."

Credit

Credit: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK

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