Captured Rotavirus Double-Layered Particles in the Midst of Producing RNA (IMAGE)

World Scientific

Captured Rotavirus Double-Layered Particles in the Midst of Producing RNA

Caption

The schematic represents an EM Affinity Grid (gray square) coated with adaptor molecules (red and dark blue) that anchor active rotavirus DLPs (yellow) to the Affi nity Grid. Cryo-Electron Microscopy (EM) image of actively transcribing DLPs reveals RNA strands (gray strands) emerging from the virus capsid. Three-dimensional image reconstructions of DLPs (light blue) that actively produce RNA reveal strong density within the viral core. Diameter of each reconstruction is ~80 nm.

Credit

Credit: Deborah F. Kelly, Virginia Tech Carilion Research Institute, Virginia Tech.

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