Two Regions of Invasive Micropapillary Carcinoma (IMAGE)
Caption
(A) This image shows the primary tumor region 1. (B) Primary tumor region 2. (C) Lymph node metastasis. Sections have been prepared from frozen surgery samples and stained by H&E. (D and E) Immunohistochemical staining for E-cadherin and epithelial membrane antigen (EMA) (glycoprotein MUC-1), respectively, in different morphological structures of IMPC. E-cadherin expression at the cell surface, EMA expression at the stromal-basal surface and an inversion of cell polarity are detected in hollow-like, morula-like, solid structures and discrete groups of tumor cells, some of whom are surrounded by empty stromal spaces (retraction clefts).
Credit
Tomsk State University
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