Alzheimer's Brain Illustration (IMAGE) Georgia Institute of Technology Caption The brain of an Alzheimer's sufferer can dramatically lose mass and shrink. In particular, center structures of the brain usually diminish early on. One such region, the hippocampus, is susceptible to early and severe damage, which can lead to memory loss and disorientation. Credit National Institute on Aging, National Institutes of Health Usage Restrictions Press handout from the NIA NIH License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.