Topologically Associating Domains (TADs) (IMAGE)

Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Topologically Associating Domains (TADs)

Caption

Within topologically associating domains (TADs), genes and their regulators interact with each other (represented by triangular shapes). Regulators like enhancers often act tissue-specific and activate their corresponding genes accordingly. A genomic inversion can alter this organization and shift the boundaries between domains. Certain regulatory elements might become associated with another gene and hence activate it in other tissues.

Credit

Thomas Splettstoesser, MPI f. mol. Genet.

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