MADM in the Snow Brain (IMAGE) Institute of Science and Technology Austria Caption The image shows a brain shaped bench (designed by Austrian artist Peter Kogel) on the IST Austria campus, reflecting an artistic representation of a MADM (Mosaic Analysis with Double Markers) brain. Snowflakes covering the bench represent the vast amount of non-labelled cells, and the colorful water balloons illustrate a very sparse genetic mosaic of neurons and glia. The differentially labelled cell populations can contain mutations for a gene of interest. By exploiting MADM-based genetic mosaics with high single cell resolution Beattie et al. discovered distinct but sequential functions of Lgl1 controlling cortical embryonic neurogenesis, postnatal astrocyte- and olfactory bulb interneuron generation. (Photograph by Maria Cristina Travaglio). Credit Maria Cristina Travaglio Usage Restrictions with credit only License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.