Diagram Depicting Dynamic Process of ZAR1 NLR Activation (IMAGE)

Chinese Academy of Sciences Headquarters

Diagram Depicting Dynamic Process of ZAR1 NLR Activation

Caption

Color-coded are PBL2, RKS1, and different domains of ZAR1. The binding of PBL2UMP as a ligand to RKS1 triggers the release of ADP from ZAR1, permitting incorporation of ATP/dATP. The binding of ATP triggers conformational changes in ZAR to expose surfaces necessary for oligomerization between neighboring ZAR1 proteins. The boxed structure highlights the death switch pupping out from the active resistosome.

Credit

WANG et al.

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