Using Single Cell RNA Sequencing, Mpg Researchers Create a Comprehensive Map of Human Liver Cells (IMAGE)

Max Planck Institute of Immunobiology and Epigenetics

Using Single Cell RNA Sequencing, Mpg Researchers Create a Comprehensive Map of Human Liver Cells

Caption

Single cells were isolated from liver tissue derived from 9 different patients to perform single-cell RNA-sequencing. After applying computational single-cell analysis methods, a human liver cell atlas, or cell type map, was established, enabling the identification of previously unknown sub-types (depicted as clusters represented by numbers on the map). We discovered rare sub-types of bile duct cells in the liver, which include a population of liver epithelial progenitors that can give rise to organoids capable of developing into hepatocytes or bile duct cells.

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MPI of Immunobiology and Epigenetics, Freiburg, Grün

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