Karl Klose, University of Texas San Antonio (IMAGE)

University of Texas at San Antonio

Karl Klose, University of Texas San Antonio

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Karl Klose, professor of biology and a researcher in UTSA's South Texas Center for Emerging Infectious Diseases, has teamed up with researchers at Ruhr University in Bochum, Germany to understand how humans get infected with cholera. Klose and his collaborators discovered that Vibrio cholerae, which normally lives in oceans and rivers, senses a shift in temperature as it enters the human body through a mechanism called a Ribonucleic Acid (RNA) thermometer. The thermometer detects the higher body temperature of 98.6 degrees Fahrenheit, and then turns on the virulence factors that lead to cholera.

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