Gene Expression and Lifespan in the Killifish (IMAGE)

Cell Press

Gene Expression and Lifespan in the Killifish

Caption

This visual abstract depicts the longitudinal transcriptome analyses that was performed in a short-lived fish by taking two fin clips during early adult life to correlate gene expression with lifespan. Gene-coexpression network analysis identified complex I of the mitochondrial respiratory chain as a hub for negative correlation with lifespan, and its pharmacological inhibition prolonged lifespan and rejuvenated the transcriptome.

Credit

Baumgart and Priebe et al./Cell Systems 2016

Usage Restrictions

Credit Required.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.