Scleroderma (IMAGE) Michigan Medicine - University of Michigan Caption Skin fibroblasts isolated from a scleroderma patient. The red fluorescence is staining alpha-smooth muscle actin, a myofibroblast marker usually seen in high levels in these patients. These activated cells are the culprit in scleroderma fibrosis. Credit Michigan Medicine Usage Restrictions Please credit Michigan Medicine and use the caption provided. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.