Gene Deletions and Duplications Reveal Our Genetic Storyline (IMAGE)

American Association for the Advancement of Science (AAAS)

Gene Deletions and Duplications Reveal Our Genetic Storyline

Caption

Counterclockwise from the top are: The geographic coordinates of populations sampled are indicated on a world map (colored dots). The pie charts show the continental population allele frequency of a single ~225 kbp duplication polymorphism found exclusively among Oceanic populations and an archaic Denisova. The ancestral structure of this duplication locus (1) and the Denisova duplication structure (2) are shown in relation to their position on chromosome 16. We estimate that the duplication emerged ~440 thousand years ago (kya) in the Denisova and then introgressed into ancestral Papuan populations ~40 kya. This material relates to a paper that appeared in the Aug. 7, 2015 issue of Science, published by AAAS. The paper, by P.H. Sudmant at University of Washington in Seattle, WA, and colleagues was titled, "Global diversity, population stratification, and selection of human copy number variation."

Credit

[Credit: Peter H. Sudmant]

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