Physical Positioning Dramatically Enhances Brain Transduction After Intrathecal AAV9 Infusion (2-7) (IMAGE)

American Association for the Advancement of Science (AAAS)

Physical Positioning Dramatically Enhances Brain Transduction After Intrathecal AAV9 Infusion (2-7)

Caption

Transduced cells cluster around blood vessels in the rat brain after intrathecal AAV9 infusion. AAV9 in the cerebrospinal fluid is thought to enter the brain by flow along the Virchow Robin spaces that surround penetrating arteries. This material relates to a paper that appeared in the Nov. 14th, 2018, issue of Science Advances, published by AAAS. The paper, by Michael J. Castle at University of California, San Diego, La Jolla, Calif., and colleagues was titled, "Physical positioning dramatically enhances brain transduction after intrathecal AAV9 infusion."

Credit

[Credit: Michael Castle and Mark Tuszynski, The University of California, San Diego]

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