Neuron and imaging (IMAGE) University of Göttingen Caption Chronic 2-photon imaging of fluorescently labelled visual cortical neurons in the living adult mouse brain: within the first 4 days of imaging, from day 0 (d0) to day 4 (d4), one dendritic spine (white dendritic protrusion) was newly formed (green arrow); after selective visual stimulation over the next 4 days (until d8), the spine was eliminated (red arrow). White arrow points to a stable spine. Dendritic spine elimination in this paradigm is usually only seen in juvenile mice, but also observed in adult PSD-95 deficient neurons, indicating that PSD-95 is necessary for synapse maturation and stabilization. Credit S Löwel Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.