'Organs in a Dish' Pave the Way for Personalized Medicine in Gut and Liver Disease (IMAGE)
Caption
Applications of organoids. Organoids can be established directly from patient tissue samples, including fresh biopsies and resected material containing either organ-specific adult stem cells (ASC) or pluripotent cells (PSC), derived from skin or blood cells, reprogrammed and then differentiated towards the desired lineage. They faithfully recapitulate the genetic and epigenetic (primary tissue-derived organoids) landscape of the patient of origin providing unique opportunities for drug screening and personalized treatment strategies. Their capacity to engraft and survive in vivo; their ability to self-organize to complex structures resembling mini-organs ex vivo; and their potential to generate bioengineered tissue, makes them optimally suited for regenerative medicine.
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<em>Digestive and Liver Disease</em>
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