Glycogen Affects Exercise Endurance (IMAGE)

Cell Press

Glycogen Affects Exercise Endurance

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This visual abstract depicts how although glycogenin is thought to be essential for glycogen synthesis, Testoni et al. show that glycogenin-deficient animals still make glycogen. Surprisingly, glycogen accumulates in striated muscle affecting functionality, including decreased exercise endurance. These findings impact our understanding of glycogen storage disease XV where patients lack glycogenin-1 and accumulate muscle glycogen.

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Testoni et al./Cell Metabolism 2017

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