The Pyramid of Cardiovascular Risk (IMAGE) Elsevier Caption Nicotine delivery systems, including nicotine replacement therapies (NRTs), smokeless tobacco, electronic cigarettes (ECs) and combusted tobacco, can be ranked within a pyramid of cardiovascular harm, stratified by potency of nicotine delivery and the accompanying non-nicotine toxicants. NRTs have the least cardiovascular risk, and combustible tobacco products have the greatest risk. Smokeless tobacco produces and ECs likely have intermediate cardiovascular risk. Credit Holly Middlekauff, MD Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.