Acrylamide-based novel DHODH inhibitors as potential rheumatoid arthritis (RA) treatment agents (IMAGE)

Compuscript Ltd

Acrylamide-based novel DHODH inhibitors as potential rheumatoid arthritis (RA) treatment agents

Caption

Dihydroorotate dehydrogenase (DHODH) is an attracting target for the treatment of immunological diseases. A series of acrylamide-based novel DHODH inhibitors as potential rheumatoid arthritis (RA) treatment agents were designed and synthesized, among which 54 is the most potent one with good pharmacokinetic profiles and favorable in vivo anti-arthritic effects.

Credit

Acta Pharmaceutica Sinica B

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.