The Biology of Heart Disease (IMAGE) Cold Spring Harbor Laboratory Caption Leonardo da Vinci's last and greatest anatomical campaign was an investigation of the heart. Shown are two views of an ox's heart, displaying the aortic valve and coronary arteries. da Vinci regarded the three-cusped valves of the heart as a perfect example of mathematical necessity in the workings of nature. Credit Image printed with permission from Royal Collection Trust/©Her Majesty Queen Elizabeth ll 2014. Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.