ATAD5 (IMAGE)

Institute for Basic Science

ATAD5

Caption

In the face of DNA reapplication stress, ATAD5 i) removes PCNA from the stressed DNA and simultaneously ii) recruits RAD51 recombinase through protein-protein interaction. Then iii) RAD51 wraps and transforms the DNA into a stable structure. Subsequently, iv) DNA is cleaved via MUS81/SLX4 and recombined, and v) DNA replication restarts. This process keeps DNA stable under replication stress and ensures entire replication is complete.

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