Indentifying a New Kinase - Tbk1 - Playing a Vital Role in Huntington's Disease (IMAGE)

Ecole Polytechnique Fédérale de Lausanne

Indentifying a New Kinase - Tbk1 - Playing a Vital Role in Huntington's Disease

Caption

Using an in vitro kinome screen, the lab of Hilal Lashuel at EPFL identified a novel kinase (TBK1) that Phosphorylates the huntingtin protein at S13 and S16 and showed that it plays a vital role in regulating its aggregation, clearance, and toxicity. In cells, TBK1 phosphorylates HTT at S13, leads to the reduction of mutant HTT aggregates in cells and C. elegans, and protects against HTT toxicity via a mechanism that involve increasing HTT S13 phosphorylation and/or promoting the clearance of soluble HTT via autophagy.

Credit

R.N. Hegde and H. Lashuel (EPFL)

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