New research reveals potential treatment to delay and manage osteoarthritis (IMAGE)

Elsevier

New research reveals potential treatment to delay and manage osteoarthritis

Caption

Primary chondrocytes overexpressing HDAC6 genetically were generated via plasmid transfection. The up-regulation of HDAC6 can deacetylate tubulin in the microtubule system, which interferes with spatial arrangement of mitochondria, leading to degradation of the extracellular matrix (ECM) and up-regulation of reactive oxygen species (ROS). Inhibition of enzyme activity of HDAC6 by Tubastatin A reverses these results and postpones the development of osteoarthritis.

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The American Journal of Pathology

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