Gonad Removal Effects (IMAGE)

Parsemus Foundation

Gonad Removal Effects

Caption

In the intact postpubertal mammal, the hypothalamus secretes gonadotropin releasing hormone (GnRH), which stimulates the anterior pituitary to release luteinizing hormone (LH). LH stimulates the secretion on gonadal hormones, which negatively feedback to the hypothalamus and anterior pituitary to decrease the secretion of GnRH and LH, respectively. Because there is no negative feedback in the gonadectomized postpubertal mammal, LH will remain persistently elevated at supraphysiologic concentrations for the remainder of the animal's life.

Credit

Dr. Michelle Kutzler

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