Glut4 and FAHFAs (IMAGE)
Caption
The protein Glut4 moves to the cell surface to help transport glucose from the blood into the cell after a meal. The left column shows total amount of Glut4 (green) in the cell and the right shows how much Glut4 (red) bounded to the cell surface, a sign of being positioned to facilitate the entry of glucose into the cell. The first row, with no insulin present, shows very little Glut4 moving to the cell surface (top right, red). The second row, with a small amount of insulin present, shows some Glut 4 on the cell surface (center right, red). The third row shows the same amount of insulin present together with a FAHFA lipid, resulting in much more Glut4 on the cell surface, which enhances the amount of glucose that can enter the cell (bottom right, red).
Credit
Weill Cornell Medical Center, Salk Institute and Beth Israel Deaconess Medical Center
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