Hierarchical Clustering Analysis of Gene Expression in Tumor Cells, Hybrid Cells and Normal Tissue (IMAGE)

American Institute of Physics

Hierarchical Clustering Analysis of Gene Expression in Tumor Cells, Hybrid Cells and Normal Tissue

Caption

The exact mechanisms for how broken cellular function appears in cells far removed from a cancer's primary tumor remain an area of ongoing research. Scientists have now confirmed a link between healthy-tumor hybrid cells and metastatic tumors for the first time in live animals. In APL Bioengineering, they discuss how they studied the distinct, heterogenous gene expression profiles found in human hybrid cells and how hybrid cells spontaneously occur in mouse models. In this image, hierarchical clustering analysis of gene expression in tumor cells (left), hybrid cells (center) and normal mouse tissue cells (right), when compared to the average expression of all genes in the display.

Credit

Gabriel Jacobs, Tanner McArdle and Brian T. Freeman

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