Super-Resolution Whole-Cell Imaging with Spinning Disc Confocal Microscopes (IMAGE)

Wyss Institute for Biologically Inspired Engineering at Harvard

Super-Resolution Whole-Cell Imaging with Spinning Disc Confocal Microscopes

Caption

The researchers used their SDC-PAINT method to visualize the network of cytoskeletal microtubule filaments (green) and their proximity with two additional proteins called TOM20 (red) and HSP60 (blue). Each image shows the proteins in a different plane of the cell starting from the top, and the magnified images on the bottom compare the resolution achieved with SDC-PAINT (left) to that possible with conventional confocal microscopy (right).

Credit

Florian Schueder, MPI/LMU

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