<b>Figure. <i>Streptococcus pyogenes</i> on the skin up-regulates the ADI pathway, leading to bacterial survival and disease. </b> (IMAGE)

Osaka University

<b>Figure. <i>Streptococcus pyogenes</i> on the skin up-regulates the ADI pathway, leading to bacterial survival and disease. </b>

Caption

WT indicates wild-type <i>S. pyogenes</i> (blue cells) that up-regulate ADI under low-glucose conditions, such as the skin surface. When ADI is activated, the bacteria can survive using arginine instead of glucose: virulent bacteria penetrate and damage the skin. <i>&Delta;ADI</i> indicates <i>S. pyogenes</i> that has been genetically modified to inactivate the ADI pathway (red cells), leading to low virulence. In blood, ADI is suppressed by high glucose levels.

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Osaka University

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