G4 selection (IMAGE)

Penn State

G4 selection

Caption

Illustration showing trends in the levels of purifying selection (purple) and thermostability (green) in G-quadruplexes (G4s)--sequences in the human genome that can fold into unusual three-dimensional structures--across different regions of the genome (shown at bottom). A new genome-wide study shows increased selection and stability of G4s in gene-regulatory regions and suggests that the unusual structures should be added to the list of functional elements in the genome.

Credit

Kateryna Makova and Dani Zemba, Penn State

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