Down-Regulation of Pulmonary AQP-5 in AKI and its Recovery by AST-120 Treatment (IMAGE)
Caption
Indoxyl sulfate chemical formula (A left) and the epithelial sodium channel of lung alveolar cells (A-right). AQP-5 and Na+/K+-ATPase protein expressions of the lung in BNx rats. Protein expressions of AQP-5 and Na+/K+-ATPase of the lung in sham-operated rats (sham), BNx rats with (BNx + AST-120) or without (BNx) oral administration of AST-120 (2.5 g/kg) at 48hr, were determined by Western blot analysis (B, C) and Immunohistochemical analysis (D) with antibody against rAQP-5. Each column represents the mean +/- S.D. from 3 rats. **p < 0.01 versus sham; # p <0.05 versus BNx. Scale bars represent 20 micrometers. [Image and caption adapted from N. Yabuuchi, M. Sagata, C. Saigo, G. Yoneda, Y. Yamamoto, Y. Nomura, K. Nishi, R. Fujino, H. Jono, and H. Saito, 'Indoxyl sulfate as a mediator involved in dysregulation of pulmonary aquaporin-5 in acute lung injury caused by acute kidney injury,' International Journal of Molecular Sciences, vol. 18, p. 11, Dec. 2016. DOI: 10.3390/ijms18010011]
Credit
Dr. Hideyuki Saito
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