Macrophages from An African Spiny Mouse Promote Tissue Regeneration (IMAGE)
Caption
Using African spiny mice, the researchers depleted macrophages in the ear pinna and found these cells were required to initiate a regenerative response to injury. When they allowed macrophages to re-invade the wound site, regeneration occurred. When the team looked at different types of macrophages in healing tissue they found that a pro-inflammatory type of macrophage was highly abundant during scarring, but very rare during regeneration.
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University of Kentucky
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