Figure 1 (IMAGE)
Caption
(A) NNMT catalyzes the methylation of nicotinamide to produce 1-methylnicotinamide (1-MNA). 1-MNA can be further oxidized by aldehyde oxidase into, N1-methyl-2- pyridone-5-carboxamide (2py) or N1-methyl-4-pyridone-3-carboxamide (4py), and all three metabolites are excreted in the urine. (B) Pillar[n]arenes, which were first reported by Ogoshi’s group in 2008, are a family of pillar-shaped macrocyclic compounds that contain a para-bridge connection between the 1,4-dialkoxybenzene units. They have an electron-rich cavity that has host–guest properties, and it is known that pillar[n]arenes form stable complexes with cations. A water-soluble pillar[6] arene (P6A) is carrying 12 carboxylate anions. The diameter across the cavity of P6A is approximately 0.67 nm.
Credit
Kanazawa University
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