Lung pathologic changes & bronchoalveolar lavage inflammatory cellular signatures during course of lethal-influenza infection (IMAGE)
Caption
These findings provide important clues regarding the inflammatory cellular signature at different time intervals during severe influenza infection. Temporal dynamics in hematoxylin and eosin-stained lung sections or modified Geimsa-stained bronchoalveolar lavage cells from control and lethal influenza-challenged mice were evaluated at 1, 3, 5, 6, and 8 dpi. Initial epithelial cytopathic effects were prominently seen at 1 dpi (open arrow), which spread to alveoli and were followed by the severe inflammatory phase (3-5 dpi). By 6 dpi, significant vascular leakage and collapse of the alveoli became prominent, and animals died between 8-9 dpi with severe hemorrhagic exudates (hash) with abundant proteinaceous material in the alveolar spaces (asterisk). CON-Control; DPI-Days post infection; M-macrophage; L-lymphocyte; N-neutrophil, EP-epithelial cell. Representative image was selected from 5 mice per group.
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The American Journal of Pathology
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