Splicing Mechanism (VIDEO)
Caption
The movie provides a direct view of the splicing mechanism catalyzed by the group II intron ribozymes. Magnified view of the ribozyme active site. The exon is shown in blue, the intron in green, Mg2+ ions are depicted as yellow spheres. The cleavage of the phosphodiester bond, connecting the intron and the exon of the ribozyme, occurs via a dissociative mechanism promoted by two Mg2+ ions: (i) the scissile phosphate breaks; (ii) the nucleophilic water attacks the scissile phosphate without being pre-activated by any specific base; (iii) the w
Credit
SISSA
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